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CD63 Recombinant Monoclonal Mouse Antibody (2304.63) – Biotium Choice

CD63 (clone 2304.63) is a validated recombinant mouse monoclonal antibody that recognizes the human tetraspanin protein CD63. The antibody belongs to the Biotium Choice list of select antibodies that have been formulated and validated in-house for optimal performance.

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Product Description

CD63 (clone 2304.63) is a recombinant mouse monoclonal antibody that recognizes the human tetraspanin protein CD63. This antibody belongs to the Biotium Choice list of select antibodies that have been formulated and validated in-house for optimal performance. This antibody has been validated in flow cytometry and immunofluorescence microscopy. The antibody is available unlabeled or conjugated to CF® Dyes.

The tetraspanins are integral membrane proteins expressed on cell surface and granular membranes of hematopoietic cells and are components of multi-molecular complexes with specific integrins. The tetraspanin CD63 is a lysosomal membrane glycoprotein that translocates to the plasma membrane after platelet activation. CD63 is expressed on activated platelets, monocytes and macrophages, and is weakly expressed on granulocytes, T cell and B cells. It is located on the basophilic granule membranes and on the plasma membranes of lymphocytes and granulocytes. CD63 is a member of the TM4 superfamily of leukocyte glycoproteins that includes CD9, CD37 and CD53, which contain four transmembrane regions. CD63 may play a role in phagocytic and intracellular lysosome-phagosome fusion events. CD63 deficiency is associated with Hermansky-Pudlak syndrome and is strongly expressed during the early stages of melanoma progression.

Tetraspanin proteins CD9, CD63, and CD81, are the most common proteins used as exosome markers. Tetraspanins are plasma membrane proteins with many proposed functions, including activation and sorting of other membrane proteins. They are also thought to play a role in the targeting of proteins to multivesicular bodies (MVBs) and exosomes. These tetraspanins are broadly expressed on many cell types and can therefore be detected on many types of exosomes, but their expression levels vary depending on the cell type of origin.

As an isotype control, we recommend Isotype Control, Monoclonal Mouse IgG1 Kappa (IGG1/1331) for this antibody. View our full catalog of Biotium Choice antibodies, optimized and validated for the best results in flow cytometry.

Exosome Stains and Antibodies

Biotium also offers ExoBrite™ CD63 Flow Antibody and ExoBrite™ CD63 Western Antibody that are validated for optimal detection of isolated exosomes by flow cytometry or western blotting. Learn more about our products for exosome research.

ConjugationEx/EmConc.SizeCatalog No.Dye Features
CF®405M416/452 nm100 ug/mL25 tests (125 uL)P013-405M-125CF®405M Features
100 tests (500 uL)P013-405M-500
CF®488A490/516 nm100 ug/mL25 tests (125 uL)P013-488A-125CF®488A Features
100 tests (500 uL)P013-488A-500
CF® 568562/584 nm100 ug/mL25 tests (125 uL)P013-568-125CF®568 Features
100 tests (500 uL)P013-568-500
CF® 583R585/609 nm100 ug/mL25 tests (125 uL)P013-583R-125CF®583R Features
100 tests (500 uL)P013-583R-500
CF® 647Plus652/668 nm100 ug/mL25 tests (125 uL)P013-647P-125CF®647Plus Features
100 tests (500 uL)P013-647P-500
CF®700696/721 nm100 ug/mL25 tests (125 uL)P013-700-125CF®700 Features
100 tests (500 uL)P013-700-500
R-PE496, 546, 565/576 nm100 ug/mL25 tests (125 uL)P013-RPE-125
100 tests (500 uL)P013-RPE-500
APC651/660 nm100 ug/mL25 tests (125 uL)P013-APC-125
100 tests (500 uL)P013-APC-500
Purified (BSA-free)N/A5 mg/mL1 mgP013-1MG
5 mgP013-5MG
 

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